F-defective Sendai virus vectors

Sendai virus has various natural advantages, including non-integrability, extremely high production titer, extremely high transgenic expression performance, significant target cell breadth, and no potential pathogenicity to humans.
We are committed to promoting our unique research and development of Fgene-defective Sendai virus vector technology to the world, including virus transformation into different types of products, and providing customized carrier packaging services for scientific research institutions and biopharmaceutical enterprises.

September 29,2024
Melton provides customized packaging F-defective Sendai virus service for CTSCB of the University of Hong Kong.
October 03,2024
Our company produces the "MeltonVEC-Cell Fusion Kit", which operates on the same principle as the "GenomONE-CF EX" product. The cell fusion efficiency exceeds 75%, and the usage method is nearly identical. PBS may be used to resuspend the freeze-dried product.
October 07,2024
The article discusses the research on the use of Sendai virus (SeV) for treating congenital and chemotherapy-induced infertility. The study shows that SeV successfully restores fertility in mice by enhancing KITL expression without the risk of viral gene integration. SeV therapy demonstrates potential for protecting fertility and offers new insights for future clinical applications.
October 17,2024
This article describes how one of our customers who applied MeltonVEC-Sendai iPSC Reprogramming Kit on the transduction of newborn fibroblasts into iPSCs successfully. There are detailed materials and methodology, highly illustrated results in this informative article.
October 27,2024
The MeltonVEC™-Cell Fusion Kit (HVJ-E) (Freeze Dried) has started global deliveries and has been successfully shipped to the UAE, currently completing order deliveries to other countries.
November 02,2024
This phase I study evaluated HVJ-E, an inactivated Sendai virus particle, for safety and preliminary efficacy in chemotherapy-resistant MPM. High doses led to stable disease, while low doses saw progression, indicating a dose-dependent antitumor effect with no serious adverse events. Findings support a phase II trial with higher doses. Trial registration: UMIN000019345.
November 09,2024
MeltonVEC™-Cell Fusion Kit (HVJ-E) (Freeze dried) product has now been delivered to the US customers following the UAE delivery.
November 10,2024
The passage introduces intestine-specific gene transfer (iGT), a method for delivering small molecules like siRNAs and plasmids into the intestinal epithelium of living mice using the Hemagglutinating Virus of Japan Envelope (HVJ-E). This technique offers a faster and more efficient alternative to traditional genetic engineering in mice, aiding research on intestinal stem cell-driven tissue renewal and tumorigenesis.
November 09,2024
"Oncolytic Sendai Virus Therapy of Canine Mast Cell Tumors (A Pilot Study)" is a preliminary study showing that oncolytic Sendai virus (SeV) can inhibit tumor growth in canine mast cell tumors (MCT) by selectively targeting and destroying tumor cells. This research provides early evidence for SeV as a potential cancer therapy and supports future clinical trials.
November 18,2024
This study created four healthy cynomolgus monkeys using pronuclear transfer, with minimal mtDNA carryover and stable mtDNA dynamics. It highlights the potential of this method for preventing mtDNA diseases and advancing mitochondrial replacement therapies in humans.T(The subsequent HVJ-E cell fusion reagent product procurement from the Chinese Academy of Sciences(Shanghai) has been replaced with Melton's.)
November 27,2024
This study develops lipid-polymer hybrid nanocarriers (FLNPs) to enhance gene delivery for ischemic diseases. FLNPs improve gene transfection, avoid lysosomes, and target the nucleus. Loaded with Hepatocyte Growth Factor (pHGF) and Catalase (pCAT) plasmids, FLNPs boosted cell resistance to oxidative stress and improved recovery in a mouse ischemia model, without causing metabolic disturbances. FLNPs show promise for effective gene therapy in ischemia.

About Us

Melton (Shenzhen) Biomedical Technology Company Limited makes use of the latest cutting-edge technologies in the field of life sciences to develop its core technology of the F-defective recombinant Sendai virus vectors, which have the advantages of ultra-high transfection efficiency and safety without integrating its genetic material into human chromosomes.

Melton's Mission
Our mission is committed to promoting recombinant Sendai virus vector technology to the world and contributing to the global healthcare sector. 
 

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